منابع مشابه
Diagnostic Evaluation of Schizophrenia for Genetic Studies
All previously published papers were reproduced with permission from the publishers. To Mattias and Frida The mind is its own place, and in itself Can make a Heav'n of Hell, a Hell of Heav'n-John Milton, Paradise Lost 2 3 ABSTRACT Background: Schizophrenia is one of the top-ten leading disorders causing disability worldwide. Heredity is accepted as a major causative factor but the mechanisms ar...
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The relatively high heritability of schizophrenia suggests that genetic factors play an important role in the etiology of the disorder. On the other hand, a number of environmental factors significantly influence its incidence. As few direct genetic effects have been demonstrated, and there is considerable inter-individual heterogeneity in the response to the known environmental factors, intera...
متن کاملGenetic principles and methods in high-risk studies of schizophrenia.
Recent advances in genetic epidemiology present excellent opportunities for future high-risk studies of schizophrenia. Improved methods are now available for specifying the natural boundaries of the schizophrenia spectrum and evaluating the mode of inheritance of schizophrenia and its biosocial risk factors. Path-analytic techniques permit the derivation of multifactor indices of both biologica...
متن کاملReport of a workshop on genetic linkage studies in schizophrenia.
A workshop on genetic linkage studies in schizophrenia was held at Columbia University's Arden House Conference Center in October 1989. This report summarizes the contents of invited talks by Drs. Arno Motulsky and T. Conrad Gilliam and the discussions at the five workshop sessions. Topics of the workshop sessions were (1) diagnostic boundaries and hierarchies in schizophrenia, (2) genetic mode...
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Genetic aberrations in sarcomas 10 2.1. Cytogenetic alterations 10 2.2. Molecular genetic changes 13 2.2.1. Structural alterations of cellular proto-oncogenes 13 2.2.2. Gene amplifications 13 2.2.3. Alterations of tumor suppressor genes and loss of 17 DNA sequences 2.3. Hereditary predisposition 18 3. DNA amplification 19 3.1. Structure and mechanisms of DNA amplification 20 4. Methods for dete...
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ژورنال
عنوان ژورنال: Schizophrenia Bulletin
سال: 1989
ISSN: 0586-7614,1745-1701
DOI: 10.1093/schbul/15.3.383